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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2005 2
2006 2
2007 2
2008 1
2010 1
2011 1
2018 2
2019 2
2020 1
2021 2
2022 4
2023 5
2024 2

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23 results

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Page 1
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation.
Schmitt M, Ceteci F, Gupta J, Pesic M, Böttger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisözü A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR. Schmitt M, et al. Nature. 2022 Dec;612(7939):347-353. doi: 10.1038/s41586-022-05426-1. Epub 2022 Nov 16. Nature. 2022. PMID: 36385525 Free PMC article.
Here we demonstrate that chemotherapy-induced tumour cell death in patient-derived colorectal tumour organoids causes ATP release triggering P2X4 (also known as P2RX4) to mediate an mTOR-dependent pro-survival program in neighbouring cancer cells, which renders surviving t …
Here we demonstrate that chemotherapy-induced tumour cell death in patient-derived colorectal tumour organoids causes ATP release triggering …
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B. Wang K, et al. Autophagy. 2023 Dec;19(12):3132-3150. doi: 10.1080/15548627.2023.2239042. Epub 2023 Jul 23. Autophagy. 2023. PMID: 37471054
Taken together, our results reveal a novel link between periplocin and the lysophagy machinery, and indicate periplocin as a potential therapeutic option for the treatment of CRC.Abbreviations: 3-MA: 3-methyladenine; ACACA/ACC1: acetyl-CoA carboxylase alpha; AMPK: adenosine monop …
Taken together, our results reveal a novel link between periplocin and the lysophagy machinery, and indicate periplocin as a potential thera …
The role of genetic polymorphisms in endolysosomal ion channels TPC2 and P2RX4 in cancer pathogenesis, prognosis, and diagnosis: a genetic association in the UK Biobank.
Alharbi AF, Parrington J. Alharbi AF, et al. NPJ Genom Med. 2021 Jul 12;6(1):58. doi: 10.1038/s41525-021-00221-9. NPJ Genom Med. 2021. PMID: 34253731 Free PMC article.
For the first time, we report novel associations between genetic variants of TPCN2 and P2RX4 and cancer/cancer subtypes in the UK Biobank's population. ...The P2RX4 rs25644 allele GG was associated with a high risk of prostate cancer, whereas it was associated with …
For the first time, we report novel associations between genetic variants of TPCN2 and P2RX4 and cancer/cancer subtypes in the UK Bio …
Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma.
Zhang C, Xiao J, Fa L, Jiang F, Jiang H, Zhou L, Xu Z. Zhang C, et al. BMC Ophthalmol. 2023 Aug 10;23(1):354. doi: 10.1186/s12886-023-03098-7. BMC Ophthalmol. 2023. PMID: 37563735 Free PMC article.
Finally, pan-cancer analysis evaluated these genes to be associated with CD8(+) T cell infiltration in other tumors. In conclusion, the proposed four-gene (PTPN12, IDH2, P2RX4, and KDELR2) prognostic hazard model had satisfactory prognostic ability. ...
Finally, pan-cancer analysis evaluated these genes to be associated with CD8(+) T cell infiltration in other tumors. In conclusion, the prop …
Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux.
Liu B, Chen R, Zhang Y, Huang J, Luo Y, Rosthøj S, Zhao C, Jäättelä M. Liu B, et al. Cell Rep. 2023 Feb 28;42(2):112137. doi: 10.1016/j.celrep.2023.112137. Epub 2023 Feb 17. Cell Rep. 2023. PMID: 36807142 Free PMC article.
Here, we show that CAD-induced rapid elevation in lysosomal pH is caused by a lysosomal H(+) efflux that requires P2RX4-mediated lysosomal Ca(2+) release and precedes the lysosomal membrane permeabilization. ...
Here, we show that CAD-induced rapid elevation in lysosomal pH is caused by a lysosomal H(+) efflux that requires P2RX4-mediated lyso …
A zinc metabolism-related gene signature for predicting prognosis and characteristics of breast cancer.
Hong J, Li M, Chen Y, Du Y, Song D. Hong J, et al. Front Immunol. 2024 Jan 8;14:1276280. doi: 10.3389/fimmu.2023.1276280. eCollection 2023. Front Immunol. 2024. PMID: 38259456 Free PMC article.
Quantitative PCR was used to assess the expression of each gene in the signature in breast cancer cell lines and patient samples. RESULTS: Five ZMRGs were identified (ATP7B, BGLAP, P2RX4, SLC39A11, and TH) and a risk profile was constructed for each. ...
Quantitative PCR was used to assess the expression of each gene in the signature in breast cancer cell lines and patient samples. RESULTS: F …
23 results